Single-point attachmentâ„¢
Early heparin surface technologies used the fact that heparin is strongly negatively charged and therefore will bind to cationic surfaces. Now we know better.
The problem with the simplistic approach of just using heparin's natural negative charge is that the surface will easily wear off, exposing the non-compatible device to the body. However, binding heparin covalently by the method of single-point attachment™ developed by Corline®, has proved to be a useful approach to heparin coated devices for long-term use. It results in a durable surface that is biologically active.
