CHSâ„¢ mimics nature

The inner lining of the blood vessel wall is the only fully blood compatible surface known to man. But by mimicking nature itself, Corline's CHSTM technology comes a close second.

 

The Corline® Heparin Surface - CHS™

The Corline® Heparin Surface technology, CHS™, combines the strengths of specific covalent bonding of heparin and the use of electrostatic forces to form a coherent coating. The key to this approach is a patented macromolecular heparin conjugate - CHC™. This conjugate is pre-assembled in a stand-alone proprietary procedure by attaching seventy heparin molecules to one carrier chain. The CHC™ is then shelf-stored for further use.

The Corline® Heparin Surface - CHS™

CHC™ binds to any cationic surface with very strong affinity due to the multiplicity of anionic groups. As most artificial materials are uncharged they need to be modified by a priming step to form a cationic surface. Following this priming step CHC™ will bind firmly to the cationic surface. The Corline®Heparin Surface - CHS™, is then accomplished in a straight-forward self-assembly process simply by exposing the primed surface to a dilute water solution containing CHC™, the Corline® Heparin Conjugate.

During this step, the heparin macromolecules will be evenly spread on the surface due to intra-molecular repulsion. Some heparin chains will be engaged in binding to the cationic surface whereas a majority will be oriented towards the blood interface and, hence, free to interact with antithrombin and other constituents in the circulating blood.

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